2Q6B

Design and synthesis of novel, conformationally restricted HMG-COA reductase inhibitors

2Q6B の概要

• エントリーDOI: 10.2210/pdb2q6b/pdb
• 関連するPDBエントリー: 2Q1L 2Q6C
• 分子名称: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, (3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph, statin
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 192392.89

構造登録者

Pavlovsky, A.,Pfefferkorn, J.A.,Harris, M.S.,Finzel, B.C. (登録日: 2007-06-04, 公開日: 2007-07-17, 最終更新日: 2024-02-21)

• 主引用文献: Pfefferkorn, J.A.,Choi, C.,Song, Y.,Trivedi, B.K.,Larsen, S.D.,Askew, V.,Dillon, L.,Hanselman, J.C.,Lin, Z.,Lu, G.,Robertson, A.,Sekerke, C.,Auerbach, B.,Pavlovsky, A.,Harris, M.S.,Bainbridge, G.,Caspers, N.; Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors.; Bioorg.Med.Chem.Lett., 17:4531-4537, 2007; PubMed: 17574411; DOI: 10.1016/j.bmcl.2007.05.097

実験手法

X-RAY DIFFRACTION (2 Å)