2Q5J

X-ray structure of phenylpyruvate decarboxylase in complex with 3-deaza-ThDP

Summary for 2Q5J

• Entry DOI: 10.2210/pdb2q5j/pdb
• Related: 2nxw 2q5l 2q5o 2q5q
• Descriptor: Phenylpyruvate decarboxylase, MAGNESIUM ION, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: thiamine diphosphate, asymmetric dimer of dimers, open active site loops, cofactor analogue, lyase
• Biological source: Azospirillum brasilense
• Total number of polymer chains: 2
• Total formula weight: 121548.96

Authors

Versees, W.,Spaepen, S.,Wood, M.D.,Leeper, F.J.,Vanderleyden, J.,Steyaert, J. (deposition date: 2007-06-01, release date: 2007-10-23, Last modification date: 2023-08-30)

• Primary citation: Versees, W.,Spaepen, S.,Wood, M.D.,Leeper, F.J.,Vanderleyden, J.,Steyaert, J.; Molecular mechanism of allosteric substrate activation in a thiamine diphosphate-dependent decarboxylase.; J.Biol.Chem., 282:35269-35278, 2007; PubMed: 17905741; DOI: 10.1074/jbc.M706048200

Experimental method

X-RAY DIFFRACTION (3.2 Å)