2Q55
Crystal structure of KK44 bound to HIV-1 protease
Summary for 2Q55
Entry DOI | 10.2210/pdb2q55/pdb |
Related | 2q54 |
Descriptor | Protease, PHOSPHATE ION, (5S)-N-[(1S,2S,4S)-1-BENZYL-2-HYDROXY-4-{[(2S)-3-METHYL-2-(2-OXOTETRAHYDROPYRIMIDIN-1(2H)-YL)BUTANOYL]AMINO}-5-PHENYLPENTYL]-2-OXO-3-PHENYL-1,3-OXAZOLIDINE-5-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | drug design, hiv-1 protease, protease inhibitor, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22477.31 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-05-31, release date: 2007-09-04, Last modification date: 2024-03-13) |
Primary citation | Reddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M. Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres. J.Med.Chem., 50:4316-4328, 2007 Cited by PubMed: 17696512DOI: 10.1021/jm070284z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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