2Q54
Crystal structure of KB73 bound to HIV-1 protease
Summary for 2Q54
Entry DOI | 10.2210/pdb2q54/pdb |
Related | 2Q55 |
Descriptor | Protease, PHOSPHATE ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | drug design, hiv-1 protease, protease inhibitors, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22596.38 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-05-31, release date: 2007-09-04, Last modification date: 2024-03-13) |
Primary citation | Reddy, G.S.,Ali, A.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Nathans, R.S.,Schiffer, C.A.,Rana, T.M. Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres. J.Med.Chem., 50:4316-4328, 2007 Cited by PubMed: 17696512DOI: 10.1021/jm070284z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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