2Q2Y

Crystal Structure of KSP in complex with Inhibitor 1

2Q2Y の概要

• エントリーDOI: 10.2210/pdb2q2y/pdb
• 関連するPDBエントリー: 2Q2Z
• 分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: ksp, ksp-inhibitor complex, cell cycle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P52732
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83708.90

構造登録者

Yan, Y. (登録日: 2007-05-29, 公開日: 2007-09-18, 最終更新日: 2024-02-21)

主引用文献

Roecker, A.J.,Coleman, P.J.,Mercer, S.P.,Schreier, J.D.,Buser, C.A.,Walsh, E.S.,Hamilton, K.,Lobell, R.B.,Tao, W.,Diehl, R.E.,South, V.J.,Davide, J.P.,Kohl, N.E.,Yan, Y.,Kuo, L.C.,Li, C.,Fernandez-Metzler, C.,Mahan, E.A.,Prueksaritanont, T.,Hartman, G.D.
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg.Med.Chem.Lett., 17:5677-5682, 2007

PubMed Abstract: Inspired by previous efforts in the pyrazolobenzoxazine class of KSP inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole inhibitors of KSP are described. Crystallographic evidence of binding mode and in vivo potency data is also highlighted.

PubMed: 17766111
DOI: 10.1016/j.bmcl.2007.07.074

実験手法

X-RAY DIFFRACTION (2.5 Å)