2Q1J

The discovery of glycine and related amino acid-based factor xa inhibitors

2Q1J の概要

• エントリーDOI: 10.2210/pdb2q1j/pdb
• 分子名称: Activated factor Xa heavy chain (EC 3.4.21.6), Factor X light chain (EC 3.4.21.6), CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: coagulation fxa, blood coagulation, calcium, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, polymorphism, protease, serine protease, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32505.30

構造登録者

Kohrt, J.T.,Filipski, K.J.,Cody, W.L.,Bigge, C.F.,Zhang, E.,Finzel, B.C. (登録日: 2007-05-24, 公開日: 2007-08-14, 最終更新日: 2011-07-13)

• 主引用文献: Kohrt, J.T.,Filipski, K.J.,Cody, W.L.,Bigge, C.F.,La, F.,Welch, K.,Dahring, T.,Bryant, J.W.,Leonard, D.,Bolton, G.,Narasimhan, L.,Zhang, E.,Peterson, J.T.,Haarer, S.,Sahasrabudhe, V.,Janiczek, N.,Desiraju, S.,Hena, M.,Fiakpui, C.,Saraswat, N.,Sharma, R.,Sun, S.,Maiti, S.N.,Leadley, R.,Edmunds, J.J.; The Discovery of Glycine and Related Amino Acid-Based Factor Xa Inhibitors; BIOORG.MED.CHEM., 14:4379-4392, 2006; PubMed: 16529937; DOI: 10.1016/j.bmc.2006.02.040

実験手法

X-RAY DIFFRACTION (1.9 Å)