2PZY
Structure of MK2 Complexed with Compound 76
Summary for 2PZY
Entry DOI | 10.2210/pdb2pzy/pdb |
Descriptor | MAP kinase-activated protein kinase 2, (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, STAUROSPORINE (3 entities in total) |
Functional Keywords | mk2, protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 151432.90 |
Authors | White, A.,Wu, J.P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B. (deposition date: 2007-05-18, release date: 2007-07-31, Last modification date: 2024-02-21) |
Primary citation | Wu, J.-P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B.,White, A. The discovery of carboline analogs as potent MAPKAP-K2 inhibitors Bioorg.Med.Chem.Lett., 17:4664-4669, 2007 Cited by PubMed: 17576063DOI: 10.1016/j.bmcl.2007.05.101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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