2PZY

Structure of MK2 Complexed with Compound 76

2PZY の概要

• エントリーDOI: 10.2210/pdb2pzy/pdb
• 分子名称: MAP kinase-activated protein kinase 2, (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, STAUROSPORINE (3 entities in total)
• 機能のキーワード: mk2, protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 151432.90

構造登録者

White, A.,Wu, J.P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B. (登録日: 2007-05-18, 公開日: 2007-07-31, 最終更新日: 2024-02-21)

• 主引用文献: Wu, J.-P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B.,White, A.; The discovery of carboline analogs as potent MAPKAP-K2 inhibitors; Bioorg.Med.Chem.Lett., 17:4664-4669, 2007; PubMed: 17576063; DOI: 10.1016/j.bmcl.2007.05.101

実験手法

X-RAY DIFFRACTION (2.9 Å)