2PZY

Structure of MK2 Complexed with Compound 76

2PZY の概要

分子名称MAP kinase-activated protein kinase 2, (4R)-N-[4-({[2-(DIMETHYLAMINO)ETHYL]AMINO}CARBONYL)-1,3-THIAZOL-2-YL]-4-METHYL-1-OXO-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE-6-CARBOXAMIDE, STAUROSPORINE (3 entities in total)
機能のキーワードmk2, protein kinase, transferase
由来する生物種Homo sapiens (human)
ポリマー鎖数4
分子量合計151432.9
構造登録者
主引用文献
Wu, J.-P.,Wang, J.,Abeywardane, A.,Andersen, D.,Emmanuel, M.,Gautschi, E.,Goldberg, D.R.,Kashem, M.A.,Lukas, S.,Mao, W.,Martin, L.,Morwick, T.,Moss, N.,Pargellis, C.,Patel, U.R.,Patnaude, L.,Peet, G.W.,Skow, D.,Snow, R.J.,Ward, Y.,Werneburg, B.,White, A.
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
Bioorg.Med.Chem.Lett., 17:4664-4669, 2007
PubMed: 17576063 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2007.05.101
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.9 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers313.7%8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード