2PYE

Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry TCR Clone C5C1 Complexed with MHC

2PYE の概要

• エントリーDOI: 10.2210/pdb2pye/pdb
• 関連するPDBエントリー: 2BNR 2F53 2F54 2P5E 2P5W
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Cancer/testis antigen 1B, ... (10 entities in total)
• 機能のキーワード: t-cell receptor, cdr3, phage display, mutant, high affinity, ny-eso-1, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Cytoplasm: P78358
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 96013.35

構造登録者

Sami, M.,Rizkallah, P.J.,Dunn, S.,Li, Y.,Moysey, R.,Vuidepot, A.,Baston, E.,Todorov, P.,Molloy, P.,Gao, F.,Boulter, J.M.,Jakobsen, B.K. (登録日: 2007-05-16, 公開日: 2007-09-25, 最終更新日: 2023-12-27)

• 主引用文献: Sami, M.,Rizkallah, P.J.,Dunn, S.,Molloy, P.,Moysey, R.,Vuidepot, A.,Baston, E.,Todorov, P.,Yi, L.,Gao, F.,Boulter, J.M.,Jakobsen, B.K.; Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry; Protein Eng.Des.Sel., 20:397-403, 2007; PubMed: 17644531; DOI: 10.1093/protein/gzm033

実験手法

X-RAY DIFFRACTION (2.3 Å)