2PXA

Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH and GTPG

2PXA の概要

• エントリーDOI: 10.2210/pdb2pxa/pdb
• 関連するPDBエントリー: 2PX2 2PX4 2PX5 2PX8 2PXC
• 分子名称: Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• 機能のキーワード: murray valley encephalitis virus, methyltransferase, sah, gtpg, gtp, structural genomics, oxford protein production facility, oppf, transferase
• 由来する生物種: Murray valley encephalitis virus (strain MVE-1-51)
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P05769
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62428.89

構造登録者

Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Oxford Protein Production Facility (OPPF) (登録日: 2007-05-14, 公開日: 2007-05-29, 最終更新日: 2023-08-30)

• 主引用文献: Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Bressanelli, S.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.; Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.; J.Gen.Virol., 88:2228-2236, 2007; PubMed: 17622627; DOI: 10.1099/vir.0.82757-0

実験手法

X-RAY DIFFRACTION (2.3 Å)