2PXA
Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH and GTPG
2PXA の概要
エントリーDOI | 10.2210/pdb2pxa/pdb |
関連するPDBエントリー | 2PX2 2PX4 2PX5 2PX8 2PXC |
分子名称 | Genome polyprotein [Contains: Capsid protein C (Core protein); Envelope protein M (Matrix protein); Major envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Flavivirin protease NS2B regulatory subunit; Flavivirin protease NS3 catalytic subunit; Non-structural protein 4A (NS4A); Non-structural protein 4B (NS4B); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5)], GUANOSINE-5'-TRIPHOSPHATE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
機能のキーワード | murray valley encephalitis virus, methyltransferase, sah, gtpg, gtp, structural genomics, oxford protein production facility, oppf, transferase |
由来する生物種 | Murray valley encephalitis virus (strain MVE-1-51) |
細胞内の位置 | Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P05769 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 62428.89 |
構造登録者 | Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Owens, R.J.,Stuart, D.I.,Grimes, J.M.,Oxford Protein Production Facility (OPPF) (登録日: 2007-05-14, 公開日: 2007-05-29, 最終更新日: 2023-08-30) |
主引用文献 | Assenberg, R.,Ren, J.,Verma, A.,Walter, T.S.,Alderton, D.,Hurrelbrink, R.J.,Fuller, S.D.,Bressanelli, S.,Owens, R.J.,Stuart, D.I.,Grimes, J.M. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues. J.Gen.Virol., 88:2228-2236, 2007 Cited by PubMed: 17622627DOI: 10.1099/vir.0.82757-0 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
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