2PWT

Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group

2PWT の概要

• エントリーDOI: 10.2210/pdb2pwt/pdb
• 分子名称: 22-mer of the ribosomal decoding site, DOUBLY FUNCTIONALIZED PAROMOMYCIN PM-II-162 (3 entities in total)
• 機能のキーワード: aminoglycoside; haba group; ribosomal decoding site; x-ray analysis; rna, rna-antibiotic complex, rna/antibiotic
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16078.00

構造登録者

Kondo, J.,Pachamuthu, K.,Francois, B.,Szychowski, J.,Hanessian, S.,Westhof, E. (登録日: 2007-05-13, 公開日: 2007-09-18, 最終更新日: 2024-03-13)

• 主引用文献: Kondo, J.,Pachamuthu, K.,Francois, B.,Szychowski, J.,Hanessian, S.,Westhof, E.; Crystal Structure of the Bacterial Ribosomal Decoding Site Complexed with a Synthetic Doubly Functionalized Paromomycin Derivative: a New Specific Binding Mode to an A-Minor Motif Enhances in vitro Antibacterial Activity; Chemmedchem, 2:1631-1638, 2007; PubMed: 17722211; DOI: 10.1002/cmdc.200700113

実験手法

X-RAY DIFFRACTION (1.8 Å)