2PUU

Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

Summary for 2PUU

• Entry DOI: 10.2210/pdb2puu/pdb
• Descriptor: Mitogen-activated protein kinase 14, 5-TERT-BUTYL-2-(4-METHYLPHENYL)-3-{[({4-[6-(MORPHOLIN-4-YLMETHYL)PYRIDIN-3-YL]-1-NAPHTHYL}AMINO)CARBONYL]AMINO}-1H-PYRAZOL-2-IUM (3 entities in total)
• Functional Keywords: p38alpha, map kinases, drug discovery, transferase
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm : P47811
• Total number of polymer chains: 1
• Total formula weight: 40376.31

Authors

Qian, K.C. (deposition date: 2007-05-09, release date: 2008-05-20, Last modification date: 2024-02-21)

• Primary citation: Qian, K.C.; A new class of p38 MAP kinase inhibitors based on the pyrazole-naphthyl urea scaffold; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)