2PUU

Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

2PUU の概要

• エントリーDOI: 10.2210/pdb2puu/pdb
• 分子名称: Mitogen-activated protein kinase 14, 5-TERT-BUTYL-2-(4-METHYLPHENYL)-3-{[({4-[6-(MORPHOLIN-4-YLMETHYL)PYRIDIN-3-YL]-1-NAPHTHYL}AMINO)CARBONYL]AMINO}-1H-PYRAZOL-2-IUM (3 entities in total)
• 機能のキーワード: p38alpha, map kinases, drug discovery, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm : P47811
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40376.31

構造登録者

Qian, K.C. (登録日: 2007-05-09, 公開日: 2008-05-20, 最終更新日: 2024-02-21)

• 主引用文献: Qian, K.C.; A new class of p38 MAP kinase inhibitors based on the pyrazole-naphthyl urea scaffold; To be Published,

実験手法

X-RAY DIFFRACTION (2.5 Å)