2PU4
AmpC beta-lacamase with bound covalent oxadiazole inhibitor
Summary for 2PU4
Entry DOI | 10.2210/pdb2pu4/pdb |
Related | 2PU2 |
Descriptor | Beta-lactamase, DIMETHYL SULFOXIDE, TERT-BUTYL [(1R)-2-METHYL-1-(1,3,4-OXADIAZOL-2-YL)PROPYL]CARBAMATE, ... (6 entities in total) |
Functional Keywords | ampc beta-lactamase oxadiazole, hydrolase |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 80006.81 |
Authors | Babaoglu, K.,Shoichet, B.K. (deposition date: 2007-05-08, release date: 2008-04-15, Last modification date: 2017-10-18) |
Primary citation | Babaoglu, K.,Simeonov, A.,Irwin, J.J.,Nelson, M.E.,Feng, B.,Thomas, C.J.,Cancian, L.,Costi, M.P.,Maltby, D.A.,Jadhav, A.,Inglese, J.,Austin, C.P.,Shoichet, B.K. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J.Med.Chem., 51:2502-2511, 2008 Cited by PubMed: 18333608DOI: 10.1021/jm701500e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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