2PRM

The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site

2PRM の概要

• エントリーDOI: 10.2210/pdb2prm/pdb
• 関連するPDBエントリー: 1D3G 2PRH 2PRL
• 分子名称: Dihydroorotate dehydrogenase, mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (4 entities in total)
• 機能のキーワード: protein inhibitor complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40468.97

構造登録者

Walse, B.,Dufe, V.T.,Al-Karadaghi, S. (登録日: 2007-05-04, 公開日: 2008-05-20, 最終更新日: 2023-08-30)

• 主引用文献: Walse, B.,Dufe, V.T.,Svensson, B.,Fritzson, I.,Dahlberg, L.,Khairoullina, A.,Wellmar, U.,Al-Karadaghi, S.; The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites; Biochemistry, 47:8929-8936, 2008; PubMed: 18672895; DOI: 10.1021/bi8003318

実験手法

X-RAY DIFFRACTION (3 Å)