2POB
PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709
Summary for 2POB
Entry DOI | 10.2210/pdb2pob/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, N-[(2S)-2-[(2-BENZOYLPHENYL)AMINO]-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL]ACETAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | pparg, nuclear receptor, ppar, gene regulation |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 62854.04 |
Authors | Nolte, R.T. (deposition date: 2007-04-26, release date: 2008-03-18, Last modification date: 2024-04-03) |
Primary citation | Trump, R.P.,Cobb, J.E.,Shearer, B.G.,Lambert, M.H.,Nolte, R.T.,Willson, T.M.,Buckholtz, R.G.,Zhao, S.M.,Leesnitzer, L.M.,Iannone, M.A.,Pearce, K.H.,Billin, A.N.,Hoekstra, W.J. Cocrystal structure guided array synthesis of PPARgamma inverse agonists BIOORG.MED.CHEM.LETT., 17:3916-3920, 2007 Cited by PubMed: 17533125DOI: 10.1016/j.bmcl.2007.04.111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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