2PKX

E.coli response regulator PhoP receiver domain

「2EU6」から置き換えられました

2PKX の概要

• エントリーDOI: 10.2210/pdb2pkx/pdb
• 分子名称: Transcriptional regulatory protein phoP (2 entities in total)
• 機能のキーワード: chey like fold, response regulator, transcription factor, phop, virulence, phob family, transcriptional regulator
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm (Probable): P23836
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28098.41

構造登録者

Bachhawat, P. (登録日: 2007-04-18, 公開日: 2007-05-22, 最終更新日: 2024-10-16)

主引用文献

Bachhawat, P.,Stock, A.M.
Crystal Structures of the Receiver Domain of the Response Regulator PhoP from Escherichia coli in the Absence and Presence of the Phosphoryl Analog Beryllofluoride.
J.Bacteriol., 189:5987-5995, 2007

PubMed Abstract: The response regulator PhoP is part of the PhoQ/PhoP two-component system involved in responses to depletion of extracellular Mg(2+). Here, we report the crystal structures of the receiver domain of Escherichia coli PhoP determined in the absence and presence of the phosphoryl analog beryllofluoride. In the presence of beryllofluoride, the active receiver domain forms a twofold symmetric dimer similar to that seen in structures of other regulatory domains from the OmpR/PhoB family, providing further evidence that members of this family utilize a common mode of dimerization in the active state. In the absence of activating agents, the PhoP receiver domain crystallizes with a similar structure, consistent with the previous observation that high concentrations can promote an active state of PhoP independent of phosphorylation.

PubMed: 17545283
DOI: 10.1128/JB.00049-07

実験手法

X-RAY DIFFRACTION (2.54 Å)