2PJT

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-344

2PJT の概要

• エントリーDOI: 10.2210/pdb2pjt/pdb
• 関連するPDBエントリー: 1ZTQ
• 分子名称: Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: mmps, metalloprotease, hydrolase, mmp-13, collagenase, zinc chelator, hydroxamate, hydrophobic s1', p1' group, calcium, collagen degradation, disease mutation, extracellular matrix, glycoprotein, metal-binding, polymorphism, secreted, zymogen
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P45452
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77217.60

構造登録者

Xu, Z.,Huang, A.,Lovering, F.,Levin, J.I.,Mosyak, L. (登録日: 2007-04-16, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

• 主引用文献: Huang, A.,Joseph-McCarthy, D.,Lovering, F.,Sun, L.,Wang, W.,Xu, W.,Zhu, Y.,Cui, J.,Zhang, Y.,Levin, J.I.; Structure-based design of TACE selective inhibitors: manipulations in the S1'-S3' pocket.; Bioorg.Med.Chem., 15:6170-6181, 2007; PubMed: 17606376; DOI: 10.1016/j.bmc.2007.06.031

実験手法

X-RAY DIFFRACTION (2.8 Å)