2PGR

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin

2PGR の概要

• エントリーDOI: 10.2210/pdb2pgr/pdb
• 関連するPDBエントリー: 2PGF 2QVN
• 分子名称: adenosine deaminase, ZINC ION, 2'-DEOXYCOFORMYCIN, ... (5 entities in total)
• 機能のキーワード: metallo-dependent hydrolase, structural genomics, medical structural genomics of pathogenic protozoa consortium, msgpp, structural genomics of pathogenic protozoa consortium, sgpp, psi, protein structure initiative, hydrolase
• 由来する生物種: Plasmodium vivax (malaria parasite P. vivax)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43892.96

構造登録者

Larson, E.T.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (登録日: 2007-04-10, 公開日: 2007-04-24, 最終更新日: 2023-11-15)

• 主引用文献: Larson, E.T.,Deng, W.,Krumm, B.E.,Napuli, A.,Mueller, N.,Van Voorhis, W.C.,Buckner, F.S.,Fan, E.,Lauricella, A.,DeTitta, G.,Luft, J.,Zucker, F.,Hol, W.G.,Verlinde, C.L.,Merritt, E.A.; Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.; J.Mol.Biol., 381:975-988, 2008; PubMed: 18602399; DOI: 10.1016/j.jmb.2008.06.048

実験手法