2PGJ

Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog

Summary for 2PGJ

• Entry DOI: 10.2210/pdb2pgj/pdb
• Related: 2PGL
• Descriptor: ADP-ribosyl cyclase 1, N1-CYCLIC INOSINE 5'-DIPHOSPHORIBOSE (3 entities in total)
• Functional Keywords: wild-type cd38 bound with n1-cidpr, the catalytic pocket, conformational changes of the active site, substrate analog binding, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type II membrane protein: P28907
• Total number of polymer chains: 2
• Total formula weight: 61303.07

Authors

Liu, Q.,Kriksunov, I.A.,Moreau, C.,Graeff, R.,Potter, B.V.L.,Lee, H.C.,Hao, Q. (deposition date: 2007-04-09, release date: 2007-04-24, Last modification date: 2023-08-30)

• Primary citation: Liu, Q.,Kriksunov, I.A.,Moreau, C.,Graeff, R.,Potter, B.V.,Lee, H.C.,Hao, Q.; Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog; J.Biol.Chem., 282:24825-24832, 2007; PubMed: 17591784; DOI: 10.1074/jbc.M701653200

Experimental method

X-RAY DIFFRACTION (1.71 Å)