2PEV
Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.
Summary for 2PEV
Entry DOI | 10.2210/pdb2pev/pdb |
Related | 1pwd 1uso 2ACQ 2ACR 2PFH 2i16 2i17 |
Descriptor | Aldose reductase, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nadp, idd594, fidarestat |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37566.80 |
Authors | Petrova, T.,Hazemann, I.,Cousido, A.,Mitschler, A.,Ginell, S.,Joachimiak, A.,Podjarny, A. (deposition date: 2007-04-03, release date: 2007-04-17, Last modification date: 2023-08-30) |
Primary citation | Cousido-Siah, A.,Petrova, T.,Hazemann, I.,Mitschler, A.,Ruiz, F.X.,Howard, E.,Ginell, S.,Atmanene, C.,Van Dorsselaer, A.,Sanglier-Cianferani, S.,Joachimiak, A.,Podjarny, A. Crystal packing modifies ligand binding affinity: The case of aldose reductase. Proteins, 80:2552-2561, 2012 Cited by PubMed: 22752989DOI: 10.1002/prot.24136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.9 Å) |
Structure validation
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