2PEV

Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.

Summary for 2PEV

Entry DOI	10.2210/pdb2pev/pdb
Related	1pwd 1uso 2ACQ 2ACR 2PFH 2i16 2i17
Descriptor	Aldose reductase, CHLORIDE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	oxidoreductase, nadp, idd594, fidarestat
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37566.80
Authors	Petrova, T.,Hazemann, I.,Cousido, A.,Mitschler, A.,Ginell, S.,Joachimiak, A.,Podjarny, A. (deposition date: 2007-04-03, release date: 2007-04-17, Last modification date: 2023-08-30)
Primary citation	Cousido-Siah, A.,Petrova, T.,Hazemann, I.,Mitschler, A.,Ruiz, F.X.,Howard, E.,Ginell, S.,Atmanene, C.,Van Dorsselaer, A.,Sanglier-Cianferani, S.,Joachimiak, A.,Podjarny, A. Crystal packing modifies ligand binding affinity: The case of aldose reductase. Proteins, 80:2552-2561, 2012 Cited by PubMed: 22752989 DOI: 10.1002/prot.24136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.9 Å)

Structure validation