2P4Q

Crystal Structure Analysis of Gnd1 in Saccharomyces cerevisiae

Summary for 2P4Q

Entry DOI	10.2210/pdb2p4q/pdb
Descriptor	6-phosphogluconate dehydrogenase, decarboxylating 1, CITRATE ANION (3 entities in total)
Functional Keywords	rossmann fold, oxidoreductase
Biological source	Saccharomyces cerevisiae (baker's yeast)
Cellular location	Cytoplasm: P38720
Total number of polymer chains	1
Total formula weight	55001.40
Authors	He, W.,Wang, Y.,Liu, W.,Zhou, C.Z. (deposition date: 2007-03-12, release date: 2007-07-24, Last modification date: 2023-10-25)
Primary citation	He, W.,Wang, Y.,Liu, W.,Zhou, C.Z. Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1 Bmc Struct.Biol., 7:38-38, 2007 Cited by PubMed Abstract: As the third enzyme of the pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is the main generator of cellular NADPH. Both thioredoxin reductase and glutathione reductase require NADPH as the electron donor to reduce oxidized thioredoxin or glutathione (GSSG). Since thioredoxin and GSH are important antioxidants, it is not surprising that 6PGDH plays a critical role in protecting cells from oxidative stress. Furthermore the activity of 6PGDH is associated with several human disorders including cancer and Alzheimer's disease. The 3D structural investigation would be very valuable in designing small molecules that target this enzyme for potential therapeutic applications. PubMed: 17570834 DOI: 10.1186/1472-6807-7-38 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation