2P4Q

Crystal Structure Analysis of Gnd1 in Saccharomyces cerevisiae

2P4Q の概要

• エントリーDOI: 10.2210/pdb2p4q/pdb
• 分子名称: 6-phosphogluconate dehydrogenase, decarboxylating 1, CITRATE ANION (3 entities in total)
• 機能のキーワード: rossmann fold, oxidoreductase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Cytoplasm: P38720
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55001.40

構造登録者

He, W.,Wang, Y.,Liu, W.,Zhou, C.Z. (登録日: 2007-03-12, 公開日: 2007-07-24, 最終更新日: 2023-10-25)

主引用文献

He, W.,Wang, Y.,Liu, W.,Zhou, C.Z.
Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
Bmc Struct.Biol., 7:38-38, 2007

PubMed Abstract: As the third enzyme of the pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is the main generator of cellular NADPH. Both thioredoxin reductase and glutathione reductase require NADPH as the electron donor to reduce oxidized thioredoxin or glutathione (GSSG). Since thioredoxin and GSH are important antioxidants, it is not surprising that 6PGDH plays a critical role in protecting cells from oxidative stress. Furthermore the activity of 6PGDH is associated with several human disorders including cancer and Alzheimer's disease. The 3D structural investigation would be very valuable in designing small molecules that target this enzyme for potential therapeutic applications.

PubMed: 17570834
DOI: 10.1186/1472-6807-7-38

実験手法

X-RAY DIFFRACTION (2.37 Å)