2P3C
Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor
Summary for 2P3C
Entry DOI | 10.2210/pdb2p3c/pdb |
Related | 2P3A 2P3B |
Related PRD ID | PRD_000434 |
Descriptor | protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, ACETIC ACID, ... (4 entities in total) |
Functional Keywords | wild type subtype f hiv protease, tl-3 inhibitor, non-b hiv protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22570.71 |
Authors | Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. (deposition date: 2007-03-08, release date: 2007-04-24, Last modification date: 2024-04-03) |
Primary citation | Sanches, M.,Krauchenco, S.,Martins, N.H.,Gustchina, A.,Wlodawer, A.,Polikarpov, I. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369:1029-1040, 2007 Cited by PubMed: 17467738DOI: 10.1016/j.jmb.2007.03.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report