2P33

Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors

2P33 の概要

• エントリーDOI: 10.2210/pdb2p33/pdb
• 分子名称: c-Jun N-terminal kinase 3, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3 entities in total)
• 機能のキーワード: jnk3 kinase, inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42515.62

構造登録者

Ceska, T.A.,Platt, A.,Fortunato, M.,Dickson, K.M.,Sharpe, A. (登録日: 2007-03-08, 公開日: 2007-06-19, 最終更新日: 2023-08-30)

主引用文献

Alam, M.,Beevers, R.E.,Ceska, T.,Davenport, R.J.,Dickson, K.M.,Fortunato, M.,Gowers, L.,Haughan, A.F.,James, L.A.,Jones, M.W.,Kinsella, N.,Lowe, C.,Meissner, J.W.,Nicolas, A.L.,Perry, B.G.,Phillips, D.J.,Pitt, W.R.,Platt, A.,Ratcliffe, A.J.,Sharpe, A.,Tait, L.J.
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
Bioorg.Med.Chem.Lett., 17:3463-3467, 2007

PubMed Abstract: The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.

PubMed: 17459703
DOI: 10.1016/j.bmcl.2007.03.078

実験手法

X-RAY DIFFRACTION (2.4 Å)