2P15

Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol

Summary for 2P15

Entry DOI	10.2210/pdb2p15/pdb
Descriptor	Estrogen receptor, GRIP peptide, (17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL, ... (4 entities in total)
Functional Keywords	nulear receptor, ligand binding domain, helix 12, hormone receptor
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596
Total number of polymer chains	4
Total formula weight	62817.98
Authors	Bruning, J.B.,Nettles, K.W.,Greene, G.L.,Kim, Y. (deposition date: 2007-03-02, release date: 2007-05-01, Last modification date: 2024-02-21)
Primary citation	Nettles, K.W.,Bruning, J.B.,Gil, G.,O'Neill, E.E.,Nowak, J.,Guo, Y.,Kim, Y.,DeSombre, E.R.,Dilis, R.,Hanson, R.N.,Joachimiak, A.,Greene, G.L. Structural plasticity in the oestrogen receptor ligand-binding domain. Embo Rep., 8:563-568, 2007 Cited by PubMed: 17468738 DOI: 10.1038/sj.embor.7400963 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation