2P15
Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol
Summary for 2P15
Entry DOI | 10.2210/pdb2p15/pdb |
Descriptor | Estrogen receptor, GRIP peptide, (17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL, ... (4 entities in total) |
Functional Keywords | nulear receptor, ligand binding domain, helix 12, hormone receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 62817.98 |
Authors | Bruning, J.B.,Nettles, K.W.,Greene, G.L.,Kim, Y. (deposition date: 2007-03-02, release date: 2007-05-01, Last modification date: 2024-02-21) |
Primary citation | Nettles, K.W.,Bruning, J.B.,Gil, G.,O'Neill, E.E.,Nowak, J.,Guo, Y.,Kim, Y.,DeSombre, E.R.,Dilis, R.,Hanson, R.N.,Joachimiak, A.,Greene, G.L. Structural plasticity in the oestrogen receptor ligand-binding domain. Embo Rep., 8:563-568, 2007 Cited by PubMed: 17468738DOI: 10.1038/sj.embor.7400963 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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