2OZR

MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid

Summary for 2OZR

• Entry DOI: 10.2210/pdb2ozr/pdb
• Related: 2ow9
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: crystal complex structure, matrix metalloproteinase, mmp13 catalytic domain, mmp13 specific inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P45452
• Total number of polymer chains: 8
• Total formula weight: 158258.78

Authors

Johnson, A.R.,Pavlovsky, A.G.,Ortwine, D.F.,Prior, F.,Man, C.-F.,Bornemeier, D.A.,Banotai, C.A.,Mueller, W.T.,McConnell, P.,Yan, C.H.,Baragi, V.,Lesch, C.,Roark, W.H.,Lie, J.J.,Fasquelle, V.,Wilson, M.,Robertson, D.,Datta, K.,Guzman, R.,Han, H.-K.,Dyer, R.D. (deposition date: 2007-02-27, release date: 2007-07-24, Last modification date: 2024-03-13)

• Primary citation: Johnson, A.R.,Pavlovsky, A.G.,Ortwine, D.F.,Prior, F.,Man, C.F.,Bornemeier, D.A.,Banotai, C.A.,Mueller, W.T.,McConnell, P.,Yan, C.,Baragi, V.,Lesch, C.,Roark, W.H.,Wilson, M.,Datta, K.,Guzman, R.,Han, H.K.,Dyer, R.D.; Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.; J.Biol.Chem., 282:27781-27791, 2007; PubMed: 17623656; DOI: 10.1074/jbc.M703286200

Experimental method

X-RAY DIFFRACTION (2.3 Å)