2OZK

Structure of an N-Terminal Truncated Form of Nendou (NSP15) From SARS-CORONAVIRUS

2OZK の概要

• エントリーDOI: 10.2210/pdb2ozk/pdb
• 分子名称: Uridylate-specific endoribonuclease (1 entity in total)
• 機能のキーワード: endonuclease nendou, ribonuclease, homolog of xenopus xendou, sars nsp15, n-terminal truncated construct, viral protein
• 由来する生物種: SARS coronavirus
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 154131.19

構造登録者

Saikatendu, K.,Joseph, J.,Subramanian, V.,Neuman, B.,Buchmeier, M.,Stevens, R.C.,Kuhn, P. (登録日: 2007-02-26, 公開日: 2007-05-29, 最終更新日: 2023-08-30)

• 主引用文献: Joseph, J.S.,Saikatendu, K.S.,Subramanian, V.,Neuman, B.W.,Buchmeier, M.J.,Stevens, R.C.,Kuhn, P.; Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch.; J.Virol., 81:6700-6708, 2007; PubMed: 17409150; DOI: 10.1128/JVI.02817-06

実験手法

X-RAY DIFFRACTION (2.9 Å)