2OZ2

Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)

Summary for 2OZ2

Entry DOI	10.2210/pdb2oz2/pdb
Descriptor	Cruzipain, SULFATE ION, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE, ... (4 entities in total)
Functional Keywords	cysteine protease, covalent inhibitor, vinyl sulfoneamide derived, hydrolase
Biological source	Trypanosoma cruzi
Total number of polymer chains	2
Total formula weight	47352.27
Authors	Rickert, M.,Brinen, L. (deposition date: 2007-02-23, release date: 2008-02-26, Last modification date: 2019-09-04)
Primary citation	Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J.Biol.Chem., 284:25697-25703, 2009 Cited by PubMed: 19620707 DOI: 10.1074/jbc.M109.014340 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation