2OZ2

Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)

2OZ2 の概要

• エントリーDOI: 10.2210/pdb2oz2/pdb
• 分子名称: Cruzipain, SULFATE ION, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE, ... (4 entities in total)
• 機能のキーワード: cysteine protease, covalent inhibitor, vinyl sulfoneamide derived, hydrolase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47352.27

構造登録者

Rickert, M.,Brinen, L. (登録日: 2007-02-23, 公開日: 2008-02-26, 最終更新日: 2019-09-04)

• 主引用文献: Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S.; Vinyl sulfones as antiparasitic agents and a structural basis for drug design.; J.Biol.Chem., 284:25697-25703, 2009; PubMed: 19620707; DOI: 10.1074/jbc.M109.014340

実験手法

X-RAY DIFFRACTION (1.95 Å)