2OYE

Indomethacin-(R)-alpha-ethyl-ethanolamide bound to Cyclooxygenase-1

2OYE の概要

• エントリーDOI: 10.2210/pdb2oye/pdb
• 関連するPDBエントリー: 1CQE 1EQE 1PGF 1PGG
• 分子名称: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: cox, pghs, indomethacin, nsaid, heme, oxidoreductase
• 由来する生物種: Ovis aries (sheep)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 72267.83

構造登録者

Harman, C.A.,Garavito, R.M. (登録日: 2007-02-21, 公開日: 2007-07-24, 最終更新日: 2020-07-29)

• 主引用文献: Harman, C.A.,Turman, M.V.,Kozak, K.R.,Marnett, L.J.,Smith, W.L.,Garavito, R.M.; Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.; J.Biol.Chem., 282:28096-28105, 2007; PubMed: 17656360; DOI: 10.1074/jbc.M701335200

実験手法

X-RAY DIFFRACTION (2.85 Å)