2OTK

Structure of Alzheimer Ab peptide in complex with an engineered binding protein

2OTK の概要

• エントリーDOI: 10.2210/pdb2otk/pdb
• 分子名称: Amyloid beta A4 protein, ZAb3 Affibody dimer (2 entities in total)
• 機能のキーワード: protein-peptide complex, beta-hairpin, intermolecular beta-sheet, de novo protein, peptide binding protein
• 由来する生物種: engineered binding protein; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 19967.09

構造登録者

Hoyer, W.,Hard, T. (登録日: 2007-02-08, 公開日: 2008-02-12, 最終更新日: 2019-12-04)

• 主引用文献: Hoyer, W.,Gronwall, C.,Jonsson, A.,Stahl, S.,Hard, T.; Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation.; Proc.Natl.Acad.Sci.Usa, 105:5099-5104, 2008; PubMed: 18375754; DOI: 10.1073/pnas.0711731105

実験手法

SOLUTION NMR