2OSZ

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding

2OSZ の概要

• エントリーDOI: 10.2210/pdb2osz/pdb
• 分子名称: Nucleoporin p58/p45 (2 entities in total)
• 機能のキーワード: npc, nucleoporin, structural protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Nucleus, nuclear pore complex : P70581
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 43124.76

構造登録者

Melcak, I.,Hoelz, A.,Blobel, G. (登録日: 2007-02-06, 公開日: 2007-04-10, 最終更新日: 2024-02-21)

主引用文献

Melcak, I.,Hoelz, A.,Blobel, G.
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding.
Science, 315:1729-1732, 2007

PubMed Abstract: The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.

PubMed: 17379812
DOI: 10.1126/science.1135730

実験手法

X-RAY DIFFRACTION (2.85 Å)