2OSF

Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study

2OSF の概要

• エントリーDOI: 10.2210/pdb2osf/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-MERCAPTOBENZENE-1,3-DIOL, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase ii, thioxolone, therapeutic ca inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29551.63

構造登録者

Albert, A.B.,Caroli, G.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C. (登録日: 2007-02-05, 公開日: 2008-05-27, 最終更新日: 2023-08-30)

• 主引用文献: Barrese, A.A.,Genis, C.,Fisher, S.Z.,Orwenyo, J.N.,Kumara, M.T.,Dutta, S.K.,Phillips, E.,Kiddle, J.J.,Tu, C.,Silverman, D.N.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Tripp, B.C.; Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.; Biochemistry, 47:3174-3184, 2008; PubMed: 18266323; DOI: 10.1021/bi702385k

実験手法

X-RAY DIFFRACTION (1.6 Å)