2OQA

X-ray Sequence and Crystal Structure of Luffaculin 1, a Novel Type 1 Ribosome-inactivating Protein

2OQA の概要

• エントリーDOI: 10.2210/pdb2oqa/pdb
• 分子名称: Luffaculin 1, 2-acetamido-2-deoxy-beta-D-glucopyranose, TETRAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: mixed alpha helix and beta sheet, hydrolase
• 由来する生物種: Luffa acutangula
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53114.24

構造登録者

Hou, X.,Huang, M. (登録日: 2007-01-31, 公開日: 2007-05-29, 最終更新日: 2024-12-25)

主引用文献

Hou, X.,Chen, M.,Chen, L.,Meehan, E.J.,Xie, J.,Huang, M.
X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein
Bmc Struct.Biol., 7:29-29, 2007

PubMed Abstract: Protein sequence can be obtained through Edman degradation, mass spectrometry, or cDNA sequencing. High resolution X-ray crystallography can also be used to derive protein sequence information, but faces the difficulty in distinguishing the Asp/Asn, Glu/Gln, and Val/Thr pairs. Luffaculin 1 is a new type 1 ribosome-inactivating protein (RIP) isolated from the seeds of Luffa acutangula. Besides rRNA N-glycosidase activity, luffaculin 1 also demonstrates activities including inhibiting tumor cells' proliferation and inducing tumor cells' differentiation.

PubMed: 17470286
DOI: 10.1186/1472-6807-7-29

実験手法

X-RAY DIFFRACTION (1.4 Å)