2OPR
Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
2OPR の概要
エントリーDOI | 10.2210/pdb2opr/pdb |
分子名称 | Reverse transcriptase/ribonuclease H, p51 RT, ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE (3 entities in total) |
機能のキーワード | hiv-1 reverse transcriptase, aids, nnrti, gw420867x, drug resistance, transferase |
由来する生物種 | HIV-1 M:B_HXB2R 詳細 |
細胞内の位置 | Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 113441.80 |
構造登録者 | Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.,Stammers, D.K. (登録日: 2007-01-30, 公開日: 2007-05-22, 最終更新日: 2023-12-27) |
主引用文献 | Ren, J.,Nichols, C.E.,Chamberlain, P.P.,Weaver, K.L.,Short, S.A.,Chan, J.H.,Kleim, J.P.,Stammers, D.K. Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases. J.Med.Chem., 50:2301-2309, 2007 Cited by PubMed: 17441703DOI: 10.1021/jm061117m 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
構造検証レポート
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