2OPB

Structure of K57A hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoHcy

2OPB の概要

• エントリーDOI: 10.2210/pdb2opb/pdb
• 関連するPDBエントリー: 1HNN 2G8N
• 分子名称: Phenylethanolamine N-methyltransferase, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• 機能のキーワード: methyltransferase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65100.40

構造登録者

Drinkwater, N.,Martin, J.L. (登録日: 2007-01-28, 公開日: 2007-10-09, 最終更新日: 2023-08-30)

• 主引用文献: Gee, C.L.,Drinkwater, N.,Tyndall, J.D.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L.; Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase.; J.Med.Chem., 50:4845-4853, 2007; PubMed: 17845018; DOI: 10.1021/jm0703385

実験手法

X-RAY DIFFRACTION (2.8 Å)