2OP9

Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

2OP9 の概要

• エントリーDOI: 10.2210/pdb2op9/pdb
• 分子名称: Replicase polyprotein 1ab (pp1ab, ORF1AB) 3C-like proteinase (3CL-PRO, 3CLp), NALPHA-[(BENZYLOXY)CARBONYL]-N-[(1R)-4-HYDROXY-1-METHYL-2-OXOBUTYL]-L-PHENYLALANINAMIDE (3 entities in total)
• 機能のキーワード: sars, 3clpro, proteinase, protease, hydrolase
• 由来する生物種: SARS coronavirus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67627.16

構造登録者

Craik, C.S.,Goetz, D.H. (登録日: 2007-01-27, 公開日: 2007-07-17, 最終更新日: 2023-12-27)

• 主引用文献: Goetz, D.H.,Choe, Y.,Hansell, E.,Chen, Y.T.,McDowell, M.,Jonsson, C.B.,Roush, W.R.,McKerrow, J.,Craik, C.S.; Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus.; Biochemistry, 46:8744-8752, 2007; PubMed: 17605471; DOI: 10.1021/bi0621415

実験手法

X-RAY DIFFRACTION (1.8 Å)