2OM0

Structure of human insulin in presence of urea at pH 6.5

Summary for 2OM0

Entry DOI	10.2210/pdb2om0/pdb
Related	2OLY 2OLZ 2OM1 2OMG 2OMH 2OMI
Descriptor	Insulin A chain, Insulin B chain, RESORCINOL, ... (7 entities in total)
Functional Keywords	r6 conformation, hormone
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01308 P01308
Total number of polymer chains	36
Total formula weight	108025.55
Authors	Norrman, M.,Schluckebier, G. (deposition date: 2007-01-20, release date: 2007-12-04, Last modification date: 2024-11-06)
Primary citation	Norrman, M.,Schluckebier, G. Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH. Bmc Struct.Biol., 7:83-83, 2007 Cited by PubMed Abstract: Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the years, insulin has been crystallized and characterized in a number of crystal systems. PubMed: 18093308 DOI: 10.1186/1472-6807-7-83 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation