2OIQ

Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.

2OIQ の概要

• エントリーDOI: 10.2210/pdb2oiq/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: src, kinase, imatinib, inactive, transferase
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66131.08

構造登録者

Seeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J. (登録日: 2007-01-11, 公開日: 2007-03-20, 最終更新日: 2023-08-30)

• 主引用文献: Seeliger, M.A.,Nagar, B.,Frank, F.,Cao, X.,Henderson, M.N.,Kuriyan, J.; c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.; Structure, 15:299-311, 2007; PubMed: 17355866; DOI: 10.1016/j.str.2007.01.015

実験手法

X-RAY DIFFRACTION (2.07 Å)