2OGM

The crystal structure of the large ribosomal subunit from Deinococcus radiodurans complexed with the pleuromutilin derivative SB-571519

2OGM の概要

• エントリーDOI: 10.2210/pdb2ogm/pdb
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L3, (2S,3AR,4R,5S,6S,8R,9R,9AR,10R)-2,5-DIHYDROXY-4,6,9,10-TETRAMETHYL-1-OXO-6-VINYLDECAHYDRO-3A,9-PROP[1]ENOCYCLOPENTA[8]ANNULEN-8-YL [(6-AMINOPYRIDAZIN-3-YL)CARBONYL]CARBAMATE (3 entities in total)
• 機能のキーワード: sb-571519, pleuromutilin, ptc, peptidyl transferase center, ribosome, antibiotic
• 由来する生物種: Deinococcus radiodurans; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 956380.72

構造登録者

Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yonath, A. (登録日: 2007-01-07, 公開日: 2007-05-01, 最終更新日: 2023-12-27)

• 主引用文献: Davidovich, C.,Bashan, A.,Auerbach-Nevo, T.,Yaggie, R.D.,Gontarek, R.R.,Yonath, A.; Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity.; Proc.Natl.Acad.Sci.Usa, 104:4291-4296, 2007; PubMed: 17360517; DOI: 10.1073/pnas.0700041104

実験手法

X-RAY DIFFRACTION (3.5 Å)