2OF2

crystal structure of furanopyrimidine 8 bound to lck

2OF2 の概要

• エントリーDOI: 10.2210/pdb2of2/pdb
• 関連するPDBエントリー: 2OF4
• 分子名称: Proto-oncogene tyrosine-protein kinase LCK, 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE (3 entities in total)
• 機能のキーワード: lck, kinase domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P06239
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31744.39

構造登録者

Martin, M.W. (登録日: 2007-01-02, 公開日: 2007-02-27, 最終更新日: 2023-08-30)

主引用文献

Martin, M.W.,Newcomb, J.,Nunes, J.J.,Bemis, J.E.,McGowan, D.C.,White, R.D.,Buchanan, J.L.,Dimauro, E.F.,Boucher, C.,Faust, T.,Hsieh, F.,Huang, X.,Lee, J.H.,Schneider, S.,Turci, S.M.,Zhu, X.
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties.
Bioorg.Med.Chem.Lett., 17:2299-2304, 2007

PubMed Abstract: 2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled to deduce their pharmacokinetic properties.

PubMed: 17276681
DOI: 10.1016/j.bmcl.2007.01.048

実験手法

X-RAY DIFFRACTION (2 Å)