2O4N
Crystal Structure of HIV-1 Protease (TRM Mutant) in Complex with Tipranavir
2O4N の概要
エントリーDOI | 10.2210/pdb2o4n/pdb |
分子名称 | protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, GLYCEROL, ... (4 entities in total) |
機能のキーワード | protease, viral protein |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22340.36 |
構造登録者 | Kang, L.W.,Armstrong, A.A.,Muzammil, S.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Freire, E.,Amzel, L.M. (登録日: 2006-12-04, 公開日: 2006-12-12, 最終更新日: 2023-12-27) |
主引用文献 | Muzammil, S.,Armstrong, A.A.,Kang, L.W.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Amzel, L.M.,Freire, E. Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations. J.Virol., 81:5144-5154, 2007 Cited by PubMed: 17360759DOI: 10.1128/JVI.02706-06 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
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