2O4K

Crystal Structure of HIV-1 Protease (Q7K) in Complex with Atazanavir

2O4K の概要

• エントリーDOI: 10.2210/pdb2o4k/pdb
• 分子名称: protease, CHLORIDE ION, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, ... (4 entities in total)
• 機能のキーワード: protease complex, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22349.92

構造登録者

Armstrong, A.A.,Muzammil, S.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Freire, E.,Amzel, L.M. (登録日: 2006-12-04, 公開日: 2006-12-12, 最終更新日: 2023-08-30)

• 主引用文献: Muzammil, S.,Armstrong, A.A.,Kang, L.W.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Amzel, L.M.,Freire, E.; Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.; J.Virol., 81:5144-5154, 2007; PubMed: 17360759; DOI: 10.1128/JVI.02706-06

実験手法

X-RAY DIFFRACTION (1.6 Å)