2O3U
Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
Summary for 2O3U
Entry DOI | 10.2210/pdb2o3u/pdb |
Related | 1YH3 2O3Q 2O3R 2O3S 2O3T |
Descriptor | ADP-ribosyl cyclase 1, 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM (3 entities in total) |
Functional Keywords | human cd38 e226q mutant, the catalytic pocket, ngd binding and hydrolysis, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 62119.68 |
Authors | Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q. (deposition date: 2006-12-01, release date: 2006-12-19, Last modification date: 2023-08-30) |
Primary citation | Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q. Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38 J.Biol.Chem., 282:5853-5861, 2007 Cited by PubMed: 17182614DOI: 10.1074/jbc.M609093200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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