2O3S

Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Summary for 2O3S

Related1YH3 2O3Q 2O3R 2O3T 2O3U
DescriptorADP-ribosyl cyclase 1, CYCLIC ADENOSINE DIPHOSPHATE-RIBOSE (3 entities in total)
Functional Keywordshuman cd38 e226g mutant, the catalytic pocket, cadpr formation and hydrolysis, substrate binding, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type II membrane protein P28907
Total number of polymer chains2
Total molecular weight61679.22
Authors
Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q. (deposition date: 2006-12-01, release date: 2006-12-12, Last modification date: 2011-07-13)
Primary citation
Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q.
Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38
J.Biol.Chem., 282:5853-5861, 2007
PubMed: 17182614 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M609093200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.287121.0%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution