2O0U

Crystal structure of human JNK3 complexed with N-{3-cyano-6-[3-(1-piperidinyl)propanoyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl}-1-naphthalenecarboxamide

Summary for 2O0U

• Entry DOI: 10.2210/pdb2o0u/pdb
• Descriptor: Mitogen-activated protein kinase 10, N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE (3 entities in total)
• Functional Keywords: kinase fold, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 42532.28

Authors

Rowland, P.,Somers, D. (deposition date: 2006-11-28, release date: 2007-02-27, Last modification date: 2023-12-27)

• Primary citation: Angell, R.M.,Atkinson, F.L.,Brown, M.J.,Chuang, T.T.,Christopher, J.A.,Cichy-Knight, M.,Dunn, A.K.,Hightower, K.E.,Malkakorpi, S.,Musgrave, J.R.,Neu, M.,Rowland, P.,Shea, R.L.,Smith, J.L.,Somers, D.O.,Thomas, S.A.,Thompson, G.,Wang, R.; N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.; Bioorg.Med.Chem.Lett., 17:1296-1301, 2007; PubMed: 17194588; DOI: 10.1016/j.bmcl.2006.12.003

Experimental method

X-RAY DIFFRACTION (2.1 Å)