2NZ9

Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2

Summary for 2NZ9

• Entry DOI: 10.2210/pdb2nz9/pdb
• Related: 2NYY
• Descriptor: Botulinum neurotoxin type A, AR2 monoclonal antibody, ZINC ION, ... (5 entities in total)
• Functional Keywords: botulinum, neurotoxin, fab, protein antibody complex, toxin-immune system complex, toxin/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
• Total number of polymer chains: 6
• Total formula weight: 395138.93

Authors

Stevens, R.C.,Arndt, J.W. (deposition date: 2006-11-22, release date: 2006-12-26, Last modification date: 2023-08-30)

• Primary citation: Garcia-Rodriguez, C.,Levy, R.,Arndt, J.W.,Forsyth, C.M.,Razai, A.,Lou, J.,Geren, I.,Stevens, R.C.,Marks, J.D.; Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.; Nat.Biotechnol., 25:107-116, 2007; PubMed: 17173035; DOI: 10.1038/nbt1269

Experimental method

X-RAY DIFFRACTION (3.79 Å)